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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
SRPK1
All Species:
25.76
Human Site:
S443
Identified Species:
47.22
UniProt:
Q96SB4
Number Species:
12
Phosphosite Substitution
Charge Score:
-0.17
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q96SB4
NP_003128.3
655
74325
S443
S
F
S
E
Q
H
I
S
Q
L
Q
E
S
I
R
Chimpanzee
Pan troglodytes
XP_518428
831
92792
S619
S
F
S
E
Q
H
I
S
Q
L
Q
E
S
I
R
Rhesus Macaque
Macaca mulatta
XP_001116721
831
92803
S619
S
F
S
E
Q
H
I
S
Q
L
Q
E
S
I
R
Dog
Lupus familis
XP_850330
823
92006
S611
S
F
N
E
Q
D
I
S
Q
L
Q
E
S
I
R
Cat
Felis silvestris
Mouse
Mus musculus
O70551
648
73070
S443
D
I
T
Q
L
E
E
S
I
R
A
D
T
P
S
Rat
Rattus norvegicus
NP_001020897
655
73837
T443
T
L
T
Q
Q
D
I
T
H
L
Q
E
R
I
R
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001516210
528
59280
K359
L
L
N
P
L
E
A
K
N
A
Q
K
L
K
V
Chicken
Gallus gallus
XP_419265
754
84415
S544
S
F
N
E
Q
E
I
S
H
L
Q
E
S
I
R
Frog
Xenopus laevis
NP_001085122
605
68633
S418
S
E
E
Q
E
G
S
S
A
M
K
M
T
A
N
Zebra Danio
Brachydanio rerio
NP_001074138
640
71523
T427
V
Q
D
G
E
S
L
T
A
E
L
K
D
P
R
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q03563
1003
112508
K601
T
A
P
D
H
L
V
K
M
A
Q
E
N
M
T
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P51567
427
49548
K258
V
C
Y
K
R
V
P
K
S
S
A
I
K
V
I
Baker's Yeast
Sacchar. cerevisiae
Q03656
742
83219
D517
S
N
I
S
Q
S
S
D
T
N
G
P
Y
I
S
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
78.5
78.2
76.7
N.A.
91.4
91.4
N.A.
65.5
70.1
67.6
64.7
N.A.
N.A.
N.A.
23.1
N.A.
Protein Similarity:
100
78.6
78.5
77.6
N.A.
94.6
94
N.A.
70.3
77.3
78.1
76.1
N.A.
N.A.
N.A.
37.1
N.A.
P-Site Identity:
100
100
100
86.6
N.A.
6.6
46.6
N.A.
6.6
80
13.3
6.6
N.A.
N.A.
N.A.
13.3
N.A.
P-Site Similarity:
100
100
100
93.3
N.A.
33.3
73.3
N.A.
20
86.6
46.6
33.3
N.A.
N.A.
N.A.
46.6
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
20.3
32.2
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
36
49.1
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
0
20
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
20
20
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
8
0
0
0
0
8
0
16
16
16
0
0
8
0
% A
% Cys:
0
8
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
8
0
8
8
0
16
0
8
0
0
0
8
8
0
0
% D
% Glu:
0
8
8
39
16
24
8
0
0
8
0
54
0
0
0
% E
% Phe:
0
39
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
8
0
8
0
0
0
0
8
0
0
0
0
% G
% His:
0
0
0
0
8
24
0
0
16
0
0
0
0
0
0
% H
% Ile:
0
8
8
0
0
0
47
0
8
0
0
8
0
54
8
% I
% Lys:
0
0
0
8
0
0
0
24
0
0
8
16
8
8
0
% K
% Leu:
8
16
0
0
16
8
8
0
0
47
8
0
8
0
0
% L
% Met:
0
0
0
0
0
0
0
0
8
8
0
8
0
8
0
% M
% Asn:
0
8
24
0
0
0
0
0
8
8
0
0
8
0
8
% N
% Pro:
0
0
8
8
0
0
8
0
0
0
0
8
0
16
0
% P
% Gln:
0
8
0
24
54
0
0
0
31
0
62
0
0
0
0
% Q
% Arg:
0
0
0
0
8
0
0
0
0
8
0
0
8
0
54
% R
% Ser:
54
0
24
8
0
16
16
54
8
8
0
0
39
0
16
% S
% Thr:
16
0
16
0
0
0
0
16
8
0
0
0
16
0
8
% T
% Val:
16
0
0
0
0
8
8
0
0
0
0
0
0
8
8
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
8
0
0
0
0
0
0
0
0
0
8
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _